DNase I (10mg/mL) >2.000U kunitz/mg
High Quality & Proven Performance in RNA In Vitro Transcription Reactions
DNase I is a recombinant endonuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, to release di-, tri- and oligonucleotide products (on average producing tetranucleotides) with 5’-phosphorylated and 3’-hydroxylated ends.
It acts on single-stranded DNA, double-stranded DNA, RNA-DNA hybrids and chromatin. DNase I requires bivalent cations (Mg²⁺ and Ca²⁺) for maximal activity.
GMP-grade reagent also available. Learn more.