Our experience in recombinant Enzyme Manufacturing and Molecular Biology reagents make us a world-class supplier for the enzymes required for the In Vitro Transcription

Enzymes required for the template generation and transcription, capping, tailing, avoiding inhibition and cleanup after synthesis are used daily in hundreds of labs focused on mRNA synthesis.

Being an original manufacturer of our products allows us to offer to our customers a high variety of options and flexibility to meet their unique needs. To be adapted to a broad range of applications, Canvax may customize the manufacturing of these products from Research-grade to Clinical-grade under GMP basis. It enables lab-scale to commercial-scale mRNA manufacturing in few weeks.

Click here to find out more about our Manufacturing Site, Quality Certifications, or main differences between RUO and GMP, to discover which grade is the adequate for your project.

Ready to discuss your Project?

Our Portfolio

The Canvax portfolio of In Vitro Transcription Enzymes are continuously expanded and adapted. Currently the main references are:

  • Inorganic Pyrophosphatase: PPase catalyzes the hydrolysis of inorganic pyrophosphate to form orthophosphate
  • T7 RNA Polymerase: highly specific for the T7 phage promoter to start the transcription. It is one of the most used option for the in vitro mRNA synthesis
  • SP6 RNA Polymerase: highly specific for a high specificity for bacteriophage SP6 promoter sequences
  • Vaccinia Capping System: catalyzes the addition of 7-methylguanylate cap structures (Cap 0) to the 5′ end of RNA
  • Poly A Polymerase: catalyzes the addition of several adenosine residues (polyA tail) onto the 3′ ends of RNA
  • mRNA Cap 2-O-Methyltransferase: catalyzes the addition of a methyl group at the 2′-O position of the first nucleotide adjacent to the cap structure at the 5′ end of the RNA
  • RNAse Inhibitor: helps to avoid any RNAse activity in the transcription reactions
  • DNAse I: is a DNA-specific endonuclease used to eliminate DNA templates from transcription reactions

How to start?

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